Diabetes mellitus, commonly known as diabetes, is a metabolic disease that causes high blood sugar. The hormone insulin moves sugar from the blood into your cells to be stored or used for energy. With diabetes, your body either doesn’t make enough insulin or can’t effectively use the insulin it does make.
In 2014, 8.5% of adults aged 18 years and older had diabetes. In 2016, diabetes was the direct cause of 1.6 million deaths and in 2012 high blood glucose was the cause of another 2.2 million deaths.Between 2000 and 2016, there was a 5% increase in premature mortality from diabetes. In high-income countries the premature mortality rate due to diabetes decreased from 2000 to 2010 but then increased in 2010-2016. In lower-middle-income countries, the premature mortality rate due to diabetes increased across both periods.
By contrast, the probability of dying from any one of the four main noncommunicable diseases (cardiovascular diseases, cancer, chronic respiratory diseases or diabetes) between the ages of 30 and 70 decreased by 18% globally between 2000 and 2016.
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Gymnema sylvestre is said to lower sugar cravings while reducing the rate at which sugar is absorbed into the body, potentially providing a two-fold action to combat weight gain and diabetes. Diabetes is a common disorder caused by the body’s inability to utilize (or produce) insulin properly. Lack of insulin or lack of insulin’s efficiency results in high blood sugar; this is because insulin is a hormone that is responsible for moving the glucose (blood sugar) from the blood, into the cell, to be used for energy.
Trigonella Foenum-Graecum / Fenugreek can help you manage diabetes. Studies have shown that fenugreek can slow down digestion and help lower blood sugar. In this article, we dig deeper to find out all about fenugreek for diabetes. We will take a look at its benefits, the different ways you can consume it, and how it works to control your blood sugar levels.
Azadirachta Indica / Neem is well known for its powerful antioxidant, anti-inflammatory, antipyretic, antimicrobial and antidiabetic properties. It causes hypoglycemia and peroxidation of lipid metabolites while increasing the enzymatic activities of glutathione perox-idases, catalases and superoxide dismutases to enhance the antioxidation. A study published in the Journal of Ayurveda & Integrative Medicine, found out the underlying molecular mechanism for antidiabetic property of A.indica. The study was conducted on diabetic rats, either having impaired glucose tolerance or reduced number and activity of signaling molecules of insulin or oxidation pathway of glucose. The therapy given was the extract of A. indica leaf at 400 mg/kg dose, which normalized the hyperglycemia and serum insulin level, while in lipid profile the quantity of HDL increased up to 21-folds. Looking over the insulin signaling molecules, the expression of receptors for insulin, receptor substrate-1 of insulin, phospho-IRS-1 Tyr 632, phospho-IRS-1 Ser 636, phospho-Akt Ser473 increased up to 2.24 folds while GLUT4 proteins expression increased up to 1.6 folds. This study proves the therapeutic potential and cost effectiveness of A.indica in diabetes which opens a new window in pharmacological world for making better management plan in controlling hyperglycemia
Syzygium Cumini / Jamun Tree has been valued in Ayurveda and Unani system of medication for possessing variety of therapeutic properties. It is mainly cultivated in the Eastern Africa, Madagascar, South America . The ripe part of this fruits are used to make health drinks, squashes, jellies and wine and used to treat different health problems, and most effective for diabetes mellitus. Traditionally the fruits, leaves, seeds, and bark are all used in ayurvedic medicine. Its bark contains tannins, carbohydrates and other nutritional micronutrients that help to combat with many diseases. Also, it is known to have antiinflammatory, antifungal, anti-diarrheal, anti fertility and antiulcerogenic properties. Dried jamun powder has a medicinal value and proved very effective to control diabetes mellitus. The present study was carried out with the aim to find out its biochemical estimation contains 70.5 gms of moisture, 16.2 gms of crude fibre, 12.8 mg of iron and 8.2 gms of total protein. This study will help people to generate awareness for the consumption of jamun fruit regularly to control diabetes mellitus.
Momordica charantia / Bitter Melon / Karela is a popular fruit used for the treatment of diabetes and related conditions amongst the indigenous populations of Asia, South America, India and East Africa. Abundant pre-clinical studies have documented the anti-diabetic and hypoglycaemic effects of M. charantia through various postulated mechanisms. However, clinical trial data with human subjects are limited and flawed by poor study design and low statistical power. The present article reviews the clinical data regarding the anti-diabetic potentials of M. charantia and calls for better-designed clinical trials to further elucidate its possible therapeutic effects.
Withania Coagulans / Paneer Dodi has been shown to possess varied medicinal properties. The aqueous extract of the fruits has been shown to exert hepatoprotective, antiinflammatory and antidiabetic activity. Recently, it has been reported by our research group that the aqueous extract of W. coagulans has hypoglycemic potential. The present communication is an endeavor in the direction of evaluating the in vivo hypoglycemic as well as antidiabetic effect from ethanolic extract W. coagulans fruits in streptozotocin‐induced diabetic rats so that it can be used as a value added agent for managing diabetes.
Tinospora Cordifolia / Giloy properties are highly appreciated in Ayurveda and even in recent modern researches. Several studies on its extracts (viz. immune- modulatory, anti-hyperglycemic, antioxidant, adaptogenic, hepatoprotective, hormone regulator etc.) and isolated phytoconstituents (like tinosporin, berberine, jatrorrhizine etc.) have reported that it is a preventive and curative antidiabetic herb, which are substantiated by clinical trials. Scattered information pertaining to antidiabetic potential of Tinospora is reported. Present review encompasses (i) in-depth information of reported antidiabetic activities of the plant in light of available experimental and clinical studies, and (ii) understanding on the possible mechanism of its action in combating the complex pathology of diabetes.
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