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Fenugreek : Sugar Punisher

Herbs like cinnamon and ginseng reduce glucose and lipid levels through the stimulation of insulin secretion, delay of gastric emptying, inhibiting glucosidase activity, increasing GLUT4 expression, and the activation of AMP-activated protein pathway, and inhibiting gluconeogenesis. Several medicinal plants are used for the treatment of diabetes, such as ginger, garlic, fenugreek and cumin .

Fenugreek (Trigonella foenum-graecum), is a historically used herbal plant that is popular in Africa, India, South, and Central Asia. It is traditionally used to treat several conditions, such as diabetes and obesity. It possesses antioxidant, antihyperlipidemic, antibacterial, antifungal, anti-inflammatory, and galactagogic properties.

Fenugreek's pharmacological effects are attributed to a range of bioactive compounds such as polyphenols, steroids, lipids, alkaloids, saponins, flavonoids, hydrocarbons, carbohydrates, galactomannan fiber, and amino acids. Several scientific groups examined its antidiabetic effect. A previous study showed that fenugreek increased glucose uptake in HepG2 cells is due to the overexpression of the glucose transporter (GLUT-2) and sterol regulatory element-binding protein (SREBP1C) mRNA levels . Another report by Pradeep and Srinivasan , demonstrated that when combined with 3% onion, better fenugreek antidiabetic results were seen. A potential fenugreek-based drug (Fenfuro®) was compared to Metformin in a clinical trial. Results showed that Fenfuro combined with Metformin gave better results than Metformin alone.

Diosgenin saponin is considered the most bioactive substance of fenugreek. It has antioxidative effects and plays a pivotal role in improving the diabetic status by several mechanisms. The mechanisms include β-cell renewal and insulin secretion stimulation. Besides, diosgenin elevates the mRNA transcription levels of CCAAT/enhancer-binding protein (C/EBPδ) and peroxisome proliferator-activated receptor-γ (PPAR-γ).

Other components in fenugreek include; 4-hydroxyisoleucine, which is an amino acid that enhances insulin secretion, decrease plasma triglycerides, and total cholesterol levels. Galactomannan is a carbohydrate that represents 45-60% of the seed of fenugreek. It has been shown to block the carbohydrate and lipid hydrolyzing enzymes in the digestive system, resulting in lowering the postprandial glucose level.

Although the detailed mechanisms of action of the fenugreek antidiabetic activity are yet to be identified, many studies suggest that antioxidant activity plays a significant role in hepatoprotection. Another possibility would be that fenugreek reverses protein glycation caused by hyperglycemia. Further investigations into the molecular mechanisms of actions and active components of the plant are needed.

Content Sourced from : International Journal of Functional Nutrition at Spandidos Publications.

Author Details :

The Orcid ID numbers for the following authors are: MTB,; SSAZ,; AA,; MKS,; AMES,

References :

1 Ota A and Ulrih NP: An overview of herbal products and secondary metabolites used for management of type two diabetes. Front Pharmacol. 8(436)2017.PubMed/NCBI View Article : Google Scholar

2 Choudhury H, Pandey M, Hua CK, Mun CS, Jing JK, Kong L, Ern LY, Ashraf NA, Kit SW, Yee TS, et al: An update on natural compounds in the remedy of diabetes mellitus: A systematic review. J Tradit Complement Med. 8:361–376. 2017.PubMed/NCBI View Article : Google Scholar

3 Essa R, El Sadek AM, Baset ME, Rawash MA, Sami DG, Badawy MT, Mansour ME, Attia H, Saadeldin MK and Abdellatif A: Effects of turmeric (Curcuma longa) extract in streptozocin-induced diabetic model. J Food Biochem. 43(e12988)2019.PubMed/NCBI View Article : Google Scholar

4 Bi X, Lim J and Henry CJ: Spices in the management of diabetes mellitus. Food Chem. 217:281–293. 2017.PubMed/NCBI View Article : Google Scholar

5 Governa P, Baini G, Borgonetti V, Cettolin G, Giachetti D, Magnano AR, Miraldi E and Biagi M: Phytotherapy in the management of diabetes: A Review. Molecules. 23(E105)2018.PubMed/NCBI View Article : Google Scholar

6 Adam SH, Giribabu N, Kassim N, Kumar KE, Brahmayya M, Arya A and Salleh N: Protective effect of aqueous seed extract of Vitis Vinifera against oxidative stress, inflammation and apoptosis in the pancreas of adult male rats with diabetes mellitus. Biomed Pharmacother. 81:439–452. 2016.PubMed/NCBI View Article : Google Scholar

7 Deng R: A review of the hypoglycemic effects of five commonly used herbal food supplements. Recent Pat Food Nutr Agric. 4:50–60. 2012.PubMed/NCBI View Article : Google Scholar

8 Medagama AB and Bandara R: The use of complementary and alternative medicines (CAMs) in the treatment of diabetes mellitus: Is continued use safe and effective? Nutr J. 13(102)2014.PubMed/NCBI View Article : Google Scholar

9 Basch E, Ulbricht C, Kuo G, Szapary P and Smith M: Therapeutic applications of fenugreek. Altern Med Rev. 8:20–27. 2003.PubMed/NCBI

10 Nagulapalli Venkata KC, Swaroop A, Bagchi D and Bishayee A: A small plant with big benefits: Fenugreek (Trigonella foenum-graecum Linn.) for disease prevention and health promotion. Mol Nutr Food Res. 61(1600950)2017.PubMed/NCBI View Article : Google Scholar

11 Naicker N, Nagiah S, Phulukdaree A and Chuturgoon A: Trigonella foenum-graecum seed extract, 4-hydroxyisoleucine, and metformin stimulate proximal insulin signaling and increase expression of glycogenic enzymes and GLUT2 in HepG2 cells. Metab Syndr Relat Disord. 14:114–120. 2016.PubMed/NCBI View Article : Google Scholar

12 Kumar A, Aswal S, Chauhan A, Semwal RB, Kumar A and Semwal DK: Ethnomedicinal investigation of medicinal plants of Chakrata region (Uttarakhand) used in the traditional medicine for diabetes by Jaunsari tribe. Nat Prod Bioprospect. 9:175–200. 2019.PubMed/NCBI View Article : Google Scholar

13 Pradeep SR and Srinivasan K: Amelioration of hyperglycemia and associated metabolic abnormalities by a combination of fenugreek (Trigonella foenum-graecum) seeds and onion (Allium cepa) in experimental diabetes. J Basic Clin Physiol Pharmacol. 28:493–505. 2017.PubMed/NCBI View Article : Google Scholar

14 Verma N, Usman K, Patel N, Jain A, Dhakre S, Swaroop A, Bagchi M, Kumar P, Preuss HG and Bagchi D: A multicenter clinical study to determine the efficacy of a novel fenugreek seed (Trigonella foenum-graecum) extract (Fenfuro™) in patients with type 2 diabetes. Food Nutr Res. 60(32382)2016.PubMed/NCBI View Article : Google Scholar

15 Tomcik KA, Smiles WJ, Camera DM, Hügel HM, Hawley JA and Watts R: Fenugreek increases insulin-stimulated creatine content in L6C11 muscle myotubes. Eur J Nutr. 56:973–979. 2017.PubMed/NCBI View Article : Google Scholar

16 Maritim AC, Sanders RA and Watkins JB III: Effects of alpha-lipoic acid on biomarkers of oxidative stress in streptozotocin-induced diabetic rats. J Nutr Biochem. 14:288–294. 2003.PubMed/NCBI View Article : Google Scholar

17 Aebi H: Catalase in vitro. Methods Enzymol. 105:121–126. 1984.PubMed/NCBI View Article : Google Scholar

18 Paglia DE and Valentine WN: Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 70:158–169. 1967.PubMed/NCBI

19 Habig WH, Pabst MJ, Fleischner G, Gatmaitan Z, Arias IM and Jakoby WB: The identity of glutathione S-transferase B with ligandin, a major binding protein of liver. Proc Natl Acad Sci USA. 71:3879–3882. 1974.PubMed/NCBI View Article : Google Scholar

20 Vetter HF and Vullers R: Effectiveness of enzyme substitution with pancynorm in chronic gastroduodenitis. Munch Med Wochenschr. 100:1786–1787. 1958.(In German). PubMed/NCBI

21 Szkudelski T: The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res. 50:537–546. 2001.PubMed/NCBI

22 Lenzen S: The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia. 51:216–226. 2008.PubMed/NCBI View Article : Google Scholar

23 Ozkol H, Tuluce Y, Dilsiz N and Koyuncu I: Therapeutic potential of some plant extracts used in Turkish traditional medicine on streptozocin-induced type 1 diabetes mellitus in rats. J Membr Biol. 246:47–55. 2013.PubMed/NCBI View Article : Google Scholar

24 Little RR and Roberts WL: A review of variant hemoglobins interfering with hemoglobin A1c measurement. J Diabetes Sci Technol. 3:446–451. 2009.PubMed/NCBI View Article : Google Scholar

25 Little RR and Sacks DB: HbA1c: How do we measure it and what does it mean? Curr Opin Endocrinol Diabetes Obes. 16:113–118. 2009.PubMed/NCBI View Article : Google Scholar

26 Pundir CS and Chawla S: Determination of glycated hemoglobin with special emphasis on biosensing methods. Anal Biochem. 444:47–56. 2014.PubMed/NCBI View Article : Google Scholar

27 Haeri MR, Limaki HK, White CJ and White KN: Non-insulin dependent anti-diabetic activity of (2S, 3R, 4S) 4-hydroxyisoleucine of fenugreek (Trigonella foenum graecum) in streptozotocin-induced type I diabetic rats. Phytomedicine. 19:571–574. 2012.PubMed/NCBI View Article : Google Scholar

28 Puri D, Prabhu KM and Murthy PS: Mechanism of action of a hypoglycemic principle isolated from fenugreek seeds. Indian J Physiol Pharmacol. 46:457–462. 2002.PubMed/NCBI

29 Murao K, Yu X, Imachi H, Cao WM, Chen K, Matsumoto K, Nishiuchi T, Wong NC and Ishida T: Hyperglycemia suppresses hepatic scavenger receptor class B type I expression. Am J Physiol Endocrinol Metab. 294:E78–E87. 2008.PubMed/NCBI View Article : Google Scholar

30 Noor Mohamad Zin NS, Hashim N, Samsulrizal N and Azmi NS: The protective effect of Azadirachta excelsa leaves extract and quercetin treatment on the learning and memory impairments in relation with insulin and amylin levels in the brain of streptozotocin-induced diabetic rats. J King Saud Univ Sci. 31:299–307. 2019.

31 Kalailingam P, Kannaian B, Tamilmani E and Kaliaperumal R: Efficacy of natural diosgenin on cardiovascular risk, insulin secretion, and beta cells in streptozotocin (STZ)-induced diabetic rats. Phytomedicine. 21:1154–1161. 2014.PubMed/NCBI View Article : Google Scholar

32 Hamden K, Jaouadi B, Carreau S, Aouidet A, El-Fazaa S, Gharbi N and Elfeki A: Potential protective effect on key steroidogenesis and metabolic enzymes and sperm abnormalities by fenugreek steroids in testis and epididymis of surviving diabetic rats. Arch Physiol Biochem. 116:146–155. 2010.PubMed/NCBI View Article : Google Scholar

33 Jin Y, Shi Y, Zou Y, Miao C, Sun B and Li C: Fenugreek prevents the development of STZ-induced diabetic nephropathy in a rat model of diabetes. Evid Based Complement Alternat Med. 2014(259368)2014.PubMed/NCBI View Article : Google Scholar

34 Xue WL, Li XS, Zhang J, Liu YH, Wang ZL and Zhang RJ: Effect of Trigonella foenum-graecum (fenugreek) extract on blood glucose, blood lipid and hemorheological properties in streptozotocin-induced diabetic rats. Asia Pac J Clin Nutr. 16 (Suppl 1):422–426. 2007.PubMed/NCBI

35 Xue W, Lei J, Li X and Zhang R: Trigonella foenum graecum seed extract protects kidney function and morphology in diabetic rats via its antioxidant activity. Nutr Res. 31:555–562. 2011.PubMed/NCBI View Article : Google Scholar

36 Jiang W, Gao L, Li P, Kan H, Qu J, Men L and Liu Z and Liu Z: Metabonomics study of the therapeutic mechanism of fenugreek galactomannan on diabetic hyperglycemia in rats, by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 1044-1045:8–16. 2017.PubMed/NCBI View Article : Google Scholar

37 Jiang W, Si L, Li P, Bai B, Qu J, Hou B, Zou H, Fan X, Liu Z, Liu Z, et al: Serum metabonomics study on antidiabetic effects of fenugreek flavonoids in streptozotocin-induced rats. J Chromatogr B Analyt Technol Biomed Life Sci. 1092:466–472. 2018.PubMed/NCBI View Article : Google Scholar

38 Brent JA and Rumack BH: Role of free radicals in toxic hepatic injury. II. Are free radicals the cause of toxin-induced liver injury? J Toxicol Clin Toxicol. 31:173–196. 1993.PubMed/NCBI View Article : Google Scholar

39 Elmnan A, Balgees A and Mangara JL: Effect of fenugreek (Trigonella foenm greacum) seed dietary levels on lipid profile and body weight gain of rats. Pak J Nutr. 11:1004–1008. 2012.

40 Garcia TS, Rech TH and Leitão CB: Pancreatic volume in diabetes mellitus. Pancreas. 46(e51)2017.PubMed/NCBI View Article : Google Scholar

41 Garcia TS, Rech TH and Leitão CB: Pancreatic size and fat content in diabetes: A systematic review and meta-analysis of imaging studies. PLoS One. 12(e0180911)2017.PubMed/NCBI View Article : Google Scholar

42 Raju J and Bird RP: Alleviation of hepatic steatosis accompanied by modulation of plasma and liver TNF-alpha levels by Trigonella foenum graecum (fenugreek) seeds in Zucker obese (fa/fa) rats. Int J Obes. 30:1298–1307. 2006.PubMed/NCBI View Article : Google Scholar

43 Sushma N and Devasena T: Aqueous extract of Trigonella foenum graecum (fenugreek) prevents cypermethrin-induced hepatotoxicity and nephrotoxicity. Hum Exp Toxicol. 29:311–319. 2010.PubMed/NCBI View Article : Google Scholar

44 Sharma MS and Choudhary PR: Hypolipidemic effect of fenugreek seeds and its comparison with atorvastatin on experimentally induced hyperlipidemia. J Coll Physicians Surg Pak. 24:539–542. 2014.PubMed/NCBI

45 Marzouk M, Soliman AM and Omar TY: Hypoglycemic and antioxidative effects of fenugreek and termis seeds powder in streptozotocin-diabetic rats. Eur Rev Med Pharmacol Sci. 17:559–565. 2013.PubMed/NCBI

46 Shivakumar A, Jashmitha BG and Dhruvaraj MR: Role of peroxidase in clinical assays: A short review. J Clin Nutr Diet. 3(2)2017.

47 Gaddam A, Galla C, Thummisetti S, Marikanty RK, Palanisamy UD and Rao PV: Role of fenugreek in the prevention of type 2 diabetes mellitus in prediabetes. J Diabetes Metab Disord. 14(74)2015.PubMed/NCBI View Article : Google Scholar

48 Herrera T, Navarro Del Hierro J, Fornari T, Reglero G and Martin D: Acid hydrolysis of saponin-rich extracts of quinoa, lentil, fenugreek and soybean to yield sapogenin-rich extracts and other bioactive compounds. J Sci Food Agric. 99:3157–3167. 2019.PubMed/NCBI View Article : Google Scholar

49 Srinivasan K: Plant foods in the management of diabetes mellitus: Spices as beneficial antidiabetic food adjuncts. Int J Food Sci Nutr. 56:399–414. 2005.PubMed/NCBI View Article : Google Scholar

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